||Influence of Ozone on Pentobarbital Pharmacokinetics in Mice.
Graham, J. A. ;
Menzel, D. B. ;
Mole, M. L. ;
Miller, F. J. ;
Gardner, D. E. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;Duke Univ., Durham, NC.
Laboratory animals ;
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It had been shown that 3 to 5 hr exposures to ambient concentrations of ozone (O3) increase pentobarbital-induced sleeping time in female mice, hamsters, and rats without decreasing heptatic cytochrome P-450 levels or selected mixed function oxidases. To elucidate potential mechanisms involved, clearance of pentobarbital from the blood of O3-exposed mice was examined. Pentobarbital clearance followed first-order kinetics with a one-compartment model. Mice exposed to 1960 micrograms per cu. m. (1ppm) for 5 hr had a 71% increase in the plasma half-life of pentobarbital. It therefore appears possible that pentobarbital-induced sleeping time is increased due to a decrease in hepatic metabolism of pentobarbital.