Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Influence of Nitrogen Dioxide on Xenobiotic Metabolism in Animals.
Author Graham, J. A. ; Illing, J. W. ; Miller, F. J. ; Gardner, D. E. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1983
Report Number EPA-600/D-83-062;
Stock Number PB83-239723
Additional Subjects Nitrogen dioxide ; Toxicology ; Physiological effects ; Liver ; Air pollution ; Phenobarbital ; Mice ; Laboratory animals ; Exposure ; Concentration(Composition) ; Air pollution effects(Animals) ; Xenobiotic
Library Call Number Additional Info Location Last
NTIS  PB83-239723 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 12p
Potential extrapulmonary effects of nitrogen dioxide (NO2) on hepatic xenobiotic metabolism were examined. Initial studies were conducted using pentobarbital (PEN) induced sleeping time (S.T.) in mice as an indicator of integrated mechanisms of xenobiotic clearance. A 3 hr. exposure to concentrations as low as 0.47 mg NO2/cu. m. (0.25 ppm) caused a significant increase in PEN-induced S.T. in female mice. When exposures were repeated for several days, the magnitude of the effect diminished. Investigation of sex sensitivity indicated that female mice were affected by acute exposure (3 hr./day, 1 or 2 days), but males were not. It was also observed that a 4 day (3 hr./day) exposure to 1.88 mg NO2/cu. m. (1.0 ppm) induced tolerance to the effects of 9.4 mg NO2/cu. m. (5.0 ppm). Mechanisms for the increase in PEN-induced S.T. were sought by evaluating hepatic cytochrome P-450 levels and the activity of 3 hepatic mixed function oxidases (aniline hydroxylase, aminopyrine N-demethylase and p-nitroanisole O-demethylase) in female mice exposed to concentrations of NO2 causing an increase in PEN-induced S.T. No significant effects were observed. A 3 hr. exposure to 9.4 mg NO2/cu. m. increased cytochrome P-450 levels in the lung, but not the liver, of rabbits.