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RECORD NUMBER: 27 OF 126

OLS Field Name OLS Field Data
Main Title Effect of Sodium Pentobarbital on Behavioral Thermoregulation in Rats and Mice.
Author Strek, K. S. ; Long, M. D. ; Gordon, C. J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1986
Report Number EPA/600/J-86/176;
Stock Number PB87-115101
Additional Subjects Thermoregulation ; Drugs ; Behavior ; Rats ; Mice ; Laboratory animals ; Reprints ; Sodium pentobarbital
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB87-115101 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 6p
Abstract
The experiment was designed to study the effects of sodium pentobarbital on behavioral thermoregulation in rats and mice. Male Sprague-Dawley rats were given intraperitoneal (i.p.) injections of sodium pentobarbital in doses of 0, 1, 5, 10 or 15 mg/kg and male CBA/J mice were given doses of 0, 5, 10, 15 or 30 mg/kg. The animals were immediately placed in a temperature gradient which allowed them to select their preferred ambient temperature (Ta). The preferred Ta of rats increased following a 10 mg/kg injection of sodium pentobarbital. However, the barbiturate had no effect on the preferred Ta of mice. The data suggest a peripheral action of sodium pentobarbital in rats which results in hypothermia and an appropriate compensatory behavioral selection of a warmer Ta.