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RECORD NUMBER: 22 OF 25

OLS Field Name OLS Field Data
Main Title Teratologic Evaluation of 2,3,4,6-Tetrachlorophenol (CAS No. 58-90-2) Administered to CD Rats on Gestational Days 6 through 15. Final Report.
Author George, J. D. ; Price, C. J. ; Sleet, R. B. ; Marr, M. C. ; Segal, S. A. ;
CORP Author Dynamac Corp., Rockville, MD. ;Research Triangle Inst., Research Triangle Park, NC.;Environmental Protection Agency, Washington, DC. Office of Solid Waste.
Year Published 1987
Report Number EPA-68-01-7366; EPA/530/SW-88/017A;
Stock Number PB88-176151
Additional Subjects Toxicology ; Rats ; Laboratory animals ; Dosage ; Bioassay ; Pregnancy ; Teratogenesis ; CAS 58-90-2 ; Tetrachlorophenol
Holdings
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Status
NTIS  PB88-176151 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 104p
Abstract
2,3,4,6-Tetrachlorophenol (TCP) was administered by gavage in olive oil to timed-pregnant CD rats at doses of 0, 25, 100, or 200 mg/kg/day on gestational days (gd) 6-15. No significant maternal effects were noted at 25 to 100 mg/kg/day TCP. At 200 mg/kg/day TCP, corrected maternal weight gain was significantly depressed below controls. During the post-treatment period, all TCP-exposed groups consumed significantly more food than the control group. Embryo/fetal growth and prenatal viability were not adversely affected by TCP exposure, nor was there any definitive evidence of an effect of TCP upon fetal morphological development.