||Teratologic Evaluation of 2,3,4,6-Tetrachlorophenol (CAS No. 58-90-2) Administered to CD Rats on Gestational Days 6 through 15. Final Report.
George, J. D. ;
Price, C. J. ;
Sleet, R. B. ;
Marr, M. C. ;
Segal, S. A. ;
||Dynamac Corp., Rockville, MD. ;Research Triangle Inst., Research Triangle Park, NC.;Environmental Protection Agency, Washington, DC. Office of Solid Waste.
Laboratory animals ;
CAS 58-90-2 ;
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2,3,4,6-Tetrachlorophenol (TCP) was administered by gavage in olive oil to timed-pregnant CD rats at doses of 0, 25, 100, or 200 mg/kg/day on gestational days (gd) 6-15. No significant maternal effects were noted at 25 to 100 mg/kg/day TCP. At 200 mg/kg/day TCP, corrected maternal weight gain was significantly depressed below controls. During the post-treatment period, all TCP-exposed groups consumed significantly more food than the control group. Embryo/fetal growth and prenatal viability were not adversely affected by TCP exposure, nor was there any definitive evidence of an effect of TCP upon fetal morphological development.