Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Respirable particles and mists in mouse pulmonary infectivity model : effect of chronic or intermittent exposure /
Author Bradof, Jeannie.
Other Authors
Author Title of a Work
Fenters, James D.
Ehrlich, Richard,
Gardner, Donald E.,
Ehrlich, Richard, 1924-
Gardner, Donald E., 1931-
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory,
Year Published 1978
Report Number EPA-600/1-78-036; EPA-68-02-1717
Stock Number PB 284 904
OCLC Number 52473316
Subjects Respiratory infections--Environmental aspects. ; Carbon--Health aspects.
Additional Subjects Carbon ; Respiratory infections ; Immunity ; Toxicology ; Sulfuric acid ; Mice ; Hamsters ; Laboratory animals ; Experimental data ; Exposure ; Antibodies ; Resistance ; Tables(Data) ; Histology ; Pathology ; Bacterial diseases ; Viral diseases ; Lethal dosage ; Bioassay ; Concentration(Composition) ; Mist ; Lung ; Streptococcus ; Mortality ; Environmental health ; Animal models ; Immunoglobins ; Air pollution effects(Animals) ; Toxic substances ; Histopathology
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJBD ARCHIVE EPA 600-1-78-036 Headquarters Library/Washington,DC 04/27/2012
EJBD  EPA 600-1-78-036 Headquarters Library/Washington,DC 04/22/2014
EKBD  EPA-600/1-78-036 Research Triangle Park Library/RTP, NC 06/20/2003
ELBD RPS EPA 600-1-78-036 repository copy AWBERC Library/Cincinnati,OH 10/17/2014
NTIS  PB-284 904 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 01/01/1988
Collation x, 82 p. : ill. ; 28 cm.
The effects of respirable-sized sulfuric acid mist or mixtures containing acid mist and carbon particles (A-C) on the susceptibility to bacterial and viral respiratory infection were studied in mice and hamsters. Both species showed mortalities upon single 3-hour exposure to 600 mg/cu m but not 400 mg/cu m acid mist. Scanning electron microscopic examination indicated that the most severe changes, including emphysemic-like areas in alveoli, were found after five daily 3-hour exposures to 200 mg/cu m A-C. Significantly increased mortality and decreased bacterial clearance from lungs were also observed in mice challenged with Streptococcus sp. Significantly increased mortality and pulmonary consolidation, with concomitant decreased survival time, occurred in mice challenged with influenza virus aerosol and exposed to 50 mg/cu m A-C, 3 hr/day, 5 days/week for 4 weeks. Depressed secondary immune responses, as measured by serum antibody levels, were observed in various groups of vaccinated mice exposed to pollutant. The effects of long-term exposure to mixtures of approximately 1.4 mg/cu m sulfuric acid mist and 1.5 mg/cu m carbon particles as well as carbon only were determined. Significant alterations of immunoglobulin concentration, depression of primary antibody response in spleen cells and decreased resistance to respiratory infection as measured by mortality, survival time, and pulmonary consolidation after 20 weeks of exposure were evident.
"Project officer, Donald E. Gardner." IIT Research Institute "May 1978." "EPA-600/1-78-036." Includes bibliographical references.