Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Critical health issues associated with review of the scientific criteria for carbon monoxide /
Author Raub, James. ; Grant, L. D.
Other Authors
Author Title of a Work
Grant, Lester D.
CORP Author Environmental Protection Agency, Research Triangle Park, NC. Environmental Criteria and Assessment Office.
Publisher United States Environmental Protection Agency, Office of Research and Development, Office of Health and Environmental Assessment,
Year Published 1989
Report Number EPA/600/D-91/090; ECAO-R-0308
Stock Number PB91-191304
Additional Subjects Air pollution standards ; Air quality ; Air pollution effects(Humans) ; Carbon monoxide ; Public health ; Exposure ; Dose-response relationship ; Carboxyhemoglobin ; Anoxia ; Risk assessment ; Behavior disorders ; Nervous system disorders ; Quality control ; Pollution regulations ; Biological effects ; Epidemiology ; Toxicity ; Cardiovascular system ; National Ambient Air Quality Standards ; Clean Air Act
Library Call Number Additional Info Location Last
NTIS  PB91-191304 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 01/01/1988
Collation 18 pages ; 28 cm
The Clean Air Act (CAA) requires periodic review of existing criteria that form the basis for carbon monoxide (CO) air quality standards. These air quality criteria are to reflect the latest scientific information useful in indicating the kind and extent of all identifiable effects on public health that may be expected from the presence of CO in ambient air. In keeping with the requirements of the CAA, the U.S. Environmental Protection Agency has started to review the criteria for CO. A number of critical issues germane to the review are presented. Additional session papers provide more detailed discussion of these issues. The paper discusses specific health issues pertaining to: (1) mechanisms of action of CO, particularly an evaluation of intracellular mechanisms secondary to impaired oxygen delivery caused by the formation of carboxyhemoglobin (COHb); (2) exposure assessment, including an evaluation of the accuracy and reliability of different methods for determining COHb; and (3) specific health effects occurring in groups of individuals considered to be at greatest risk to CO at ambient or near-ambient exposure levels including a reevaluation of previous dose-response functions for CO utilizing the information gained from recently completed studies. These critical issues will need to be resolved in order to determine the extent to which adverse effects are occurring in the population, particularly at the lower COHb levels of greatest interest to standard setting.
"For pesentation at the 82nd Annual Meeting and Exhibition, Anaheim, California, June 25-30, 1989." Caption title. Microfiche.,
Contents Notes