Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Effect of Sodium Pentobarbital on Behavioral Thermoregulation in Rats and Mice.
Author Strek, K. S. ; Long, M. D. ; Gordon, C. J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1986
Report Number EPA/600/J-86/176;
Stock Number PB87-115101
Additional Subjects Thermoregulation ; Drugs ; Behavior ; Rats ; Mice ; Laboratory animals ; Reprints ; Sodium pentobarbital
Library Call Number Additional Info Location Last
NTIS  PB87-115101 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 6p
The experiment was designed to study the effects of sodium pentobarbital on behavioral thermoregulation in rats and mice. Male Sprague-Dawley rats were given intraperitoneal (i.p.) injections of sodium pentobarbital in doses of 0, 1, 5, 10 or 15 mg/kg and male CBA/J mice were given doses of 0, 5, 10, 15 or 30 mg/kg. The animals were immediately placed in a temperature gradient which allowed them to select their preferred ambient temperature (Ta). The preferred Ta of rats increased following a 10 mg/kg injection of sodium pentobarbital. However, the barbiturate had no effect on the preferred Ta of mice. The data suggest a peripheral action of sodium pentobarbital in rats which results in hypothermia and an appropriate compensatory behavioral selection of a warmer Ta.