Record Display for the EPA National Library Catalog
RECORD NUMBER: 16 OF 210
|OLS Field Name||OLS Field Data|
|Main Title||Attenuation of Alcohol Consumption by MDMA (Ecstasy) in Two Strains of Alcohol-Preferring Rats.|
|Author||Rezvani, A. H. ; Garges, P. L. ; Miller, D. B. ; Gordon, C. J. ;|
|CORP Author||Environmental Protection Agency, Research Triangle Park, NC. Neurotoxicology Div. ;North Carolina Univ. at Chapel Hill.|
|Additional Subjects||Alcohol drinking ; Amphetamines ; Serotonin ; Rats ; Water consumption ; Body temperature ; Drinking behavior ; Alcoholism ; Reprints ; Methylenedioxymethamphetamine|
Alcohol preference and manifestation of alcoholism are thought by many to be associated with serotonin (5-HT) dysfunction in the brain. Thus, experiments were performed to determine the effect of acute and sub-chronic administration (s.c.) of + or - 3,4-methylenedioxymethamphetamine (MDMA), an amphetamine analog which stimulates 5-HT release, on alcohol preference in two strains of alcohol preferring rats, the Fawn-Hooded (FH) and alcohol preferring (P) rats. Our results show that a single administration of 5.0 mg/kg MDMA significantly decreased ethanol intake in both FH and P rats and increased water intake. Sub-chronic administration of 5.0 mg/kg MDMA for three consecutive days significantly attenuated alcohol intake in both strains.