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RECORD NUMBER: 11 OF 16

OLS Field Name OLS Field Data
Main Title Fimbria-Fornix Transections Disrupt the Ontogeny of Delayed Alternation but Not Position Discrimination in the Rat.
Author Freeman, J. H. ; Stanton., M. E. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina Univ. at Chapel Hill.
Publisher c1991
Year Published 1991
Report Number EPA/600/J-91/160;
Stock Number PB91-231282
Additional Subjects Surgery ; Ontogenesis ; Discrimination learning ; Rats ; Histology ; Animal behavior ; Acetylcholinesterase ; Hippocampus ; Immunohistochemistry ; Reprints ; Fimbria-fornix transections
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB91-231282 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 11/26/1991
Collation 12p
Abstract
In Experiment 1, Long-Evans rat pups received fimbria-fornix transections or sham surgery on Postnatal Day 10 (PND10) and were then trained on PND23 to perform either a discrete-trials delayed alternation (DA) or a simple position discrimination (PD) task in a T maze. Rat pups in both surgical conditions learned the PD task within five 12-trial blocks of training. However, only sham-operated pups learned the DA task. In Experiment 2, performance of DA emerged between PND19 and PND27 in sham-operated pups but failed entirely to develop in pups with early lesions. In Experiment 3, fornix-transected pups that were given extended DA training (132 trials) on PND23-PND24 showed some improvement in performance but remained impaired in relation to sham-operated controls. These findings implicate the limbic system in the postnatal development of DA but not PD and suggest that dual-process theories of memory may be relevent to the psychobiology of cognitive development.