Record Display for the EPA National Library Catalog

RECORD NUMBER: 5 OF 8

OLS Field Name OLS Field Data
Main Title Effect of Alkoxy Substituents on the Mutagenicity of Some Phenylenediamine-Based Disazo Dyes.
Author Esancy, J. F. ; Freeman, H. S. ; Claxton, L. D. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div.;North Carolina State Univ. at Raleigh.
Publisher c1990
Year Published 1990
Report Number EPA/600/J-90/014;
Stock Number PB90-217456
Additional Subjects Alkoxy compounds ; Toxicity ; Azo dyes ; Reduction(Chemistry) ; Salmonella typhimurium ; Tables(Data) ; Reprints ; Mutagenicity tests
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB90-217456 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 08/27/1990
Collation 18p
Abstract
Fifteen aminoazobenzene dyes and seven of their reductive-cleavage products were examined in the Salmonella/microsome assay with strains TA98, TA100, TA1535, TA1537 and TA1538. Dyes tested included five derivatives of 4-aminoazobenzene with different alkoxy substituents (-OCH3, -OCH2CH3, -OCH2CH2CH3, -OCH2CH2CH2CH3 or -OCH2CH2OH) in the 3-position as well as the corresponding derivatives of 4-((4-aminophenyl)azo)N,N-diethylaniline and 4-((4-aminophenyl)azo)N,N-bis(2-hydroxyethyl)aniline. In general, as the size of the substituent ortho to the primary amino group of the dyes was increased, the mutagenicity decreased. A similar trend was observed for the reductive-cleavage products. The results from the latter aspect of the study suggest that the mutagenicity of aminoazobenzene dyes can not be accounted for solely from the properties of their reductive-cleavage products. (Copyright (c) 1990 Elsevier Science Publishers B.V. (Biomedical Division).)