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RECORD NUMBER: 3 OF 4

OLS Field Name OLS Field Data
Main Title Proceedings of the Workshop on One- versus Two-Generation Reproductive Effects Studies.
Author Francis, E. Z. ; Kimmel, G. L. ;
CORP Author Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.
Publisher Nov 88
Year Published 1988
Report Number EPA/600/J-88/348;
Stock Number PB89-236459
Additional Subjects Toxicity ; Pesticides ; Meetings ; Test methods ; Reproductive system ; Biological effects ; Risk assessment
Holdings
Library Call Number Additional Info Location Last
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Status
NTIS  PB89-236459 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 12/18/1989
Collation 17p
Abstract
The purpose of the workshop was to address the central question: Is a single-generation reproductive effects study sufficient to assess the reproductive toxicity potential of chemicals that do not bioaccumulate. The panel of nine participants concluded that, by itself, a one-generation reproductive effects study is insufficient to identify all potential reproductive toxicants and that a two-generation study is needed for an adequate assessment. The panel did not support placing much importance on bioaccumulation as related to reproductive toxicity testing mainly because it is not the only critical factor that may account for effects in a second generation but not in the first. The panel accomplished several goals in directing future development in reproductive toxicity testing: (1) the purpose of a reproductive effects study was defined, (2) a minimal set of end points necessary for adequate evaluation of reproductive toxicity was determined, (3) some alternative reproductive effects test methods were recommended, (4) greater flexibility in choosing a test protocol on a case-by-case basis was encouraged, and (5) areas that need further research were identified.