Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Hepatic Neoplasms in the Mummichog 'Fundulus heteroclitus' from a Creosote-Contaminated Site.
Author Vogelbein, W. K. ; Fournie, J. W. ; Van Veld, P. A. ; Huggett, R. J. ;
CORP Author Environmental Research Lab., Gulf Breeze, FL. ;Virginia Inst. of Marine Science, Gloucester Point. ;Virginia State Water Control Board, Richmond.
Publisher 1990
Year Published 1990
Report Number EPA/600/J-90/385;
Stock Number PB91-163980
Additional Subjects Water pollution ; Toxicity ; Creosote ; Liver neoplasms ; Water pollution effects(Animals) ; Carcinogenicity tests ; Polycyclic aromatic hydrocarbons ; Sediments ; Elizabeth River(Virginia) ; Pathology ; Reprints ; Fundulus heteroclitus
Library Call Number Additional Info Location Last
NTIS  PB91-163980 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/13/1991
Collation 10p
High prevalences of idiopathic hepatic lesions were found in mummichog, Fundulus heteroclitus from a site in the southern branch of the Elizabeth River, Virginia contaminated with polycyclic aromatic hydrocarbons (PAHs). Gross hepatic lesions occurred in 93% of the individuals from this site, whereas no hepatic lesions were detected in fish from two less contaminated sites. Lesions included foci of cellular alteration, hepatocellular adenoma, early and advanced hepatocellular carcinomas and cholangiocellular proliferative lesions. Advanced carcinomas exhibited several distinct cellular patterns and some livers contained multiple neoplasms occupying up to 80% of the hepatic parenchyma. These findings indicate a strong positive association between exposure to creosote-contaminated sediments and the high prevalence of hepatic neoplasms in a feral population of mummichog, and support the putative role of PAHs in fish hepatocarcinogenesis. Additionally, they suggest that the mummichog may be a useful indicator of exposure to carcinogens in aquatic environments.