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OLS Field Name OLS Field Data
Main Title Disruption of Human Eyeblink Conditioning After Central Cholinergic Blockade with Scopolamine.
Author Solomon, P. R. ; Groccia-Ellison, M. ; Flynn, D. ; Mirak, J. ; Edwards, K. R. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1993
Year Published 1993
Report Number EPA/600/J-93/362;
Stock Number PB93-228880
Additional Subjects Scopolamine ; Cholinergic receptors ; Eyelid conditioning ; Pharmacology ; Humans ; Auditory threshold ; Cognition ; Reprints ;
Holdings
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NTIS  PB93-228880 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 11/22/1993
Collation 11p
Abstract
Human volunteers (N = 72) received saline, a low dose of oral scopolamine (0.6 mg), a high dose of oral scopolamine (1.2 mg), or a peripheral analogue (glycopyrrolate). They then underwent classical conditioning of the eyeblink response to a tone conditioned stimulus (CS) and a corneal airpuff unconditioned stimulus (UCS) in a delay conditioning paradigm. There was a dose-related decline in acquisition of the conditioned response. These drug-induced conditioning deficits were similar to those previously reported in rabbit eyeblink conditioning and could not be attributed to such nonassociative factors as changes in auditory thresholds to the tone CS, magnitude of reflexive blinks to the airpuff UCS, or to changes in spontaneous blink rates. (Copyright (c) 1993 by the American Psychological Association, Inc.)