||Prenatal Exposure to the Fungicide Dinocap Causes Behavioral Toricollis, Ballooning and Cleft Palate in Mice, but not Rats or Hamsters.
Gray, L. E. ;
Rogers, J. M. ;
Kavlock, R. J. ;
Ostby, J. S. ;
Ferrell, J. M. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC.
Laboratory animals ;
In vivo analysis ;
Crotonic acid/(dinitrophenyl-ester)-heptyl-methyl ;
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The present study is an evaluation of the developmental toxicity of dinocap in three rodent species using an in vivo teratology screen. The protocol uses postnatal viability, weight gain and morphological and behavioral development through weaning to assess the developmental toxicity of compounds. Dinocap administered orally on days 7 to 16 of gestation to the CD-1 mouse resulted in increased postnatal mortality at 25mg/kg/d (80% in block 1 and 40% in block 2). Many of the treated pups that died during the neonatal period were 'ballooned' and had cleft palates. Although there was no treatment related mortality in the 12mg/kg/d dosage group, 7% (15/221) of these mice and 24% (21/85) of the survivors from the 25mg/kg/d dosage group displayed torticollis (a twisting of the neck resulting in an abnormal tilting of the head). These tilted head mice held the head and forepart of the body tilted constantly to one side, both when resting and walking. The tilt was in either direction but was always constant for a given animal; in different mice the angle varied considerably from almost 0 to 30 degrees.