Record Display for the EPA National Library Catalog

RECORD NUMBER: 13 OF 13

OLS Field Name OLS Field Data
Main Title Thyroid Follicular Cell Carcinogenesis: Mechanistic and Science Policy Considerations.
Author Hill, R. N. ; Erdreich, L. S. ; Paynter, O. E. ; Roberts, P. A. ; Rosenthal, S. L. ;
CORP Author Environmental Protection Agency, Washington, DC. Office of Research and Development.
Year Published 1988
Report Number EPA/625/3-88/014A;
Stock Number PB88-230750
Additional Subjects Thyroid gland ; Endocrine gland ; Thyroid neoplasms ; Exposure ; Carcinogen risk assessment ; Carcinogenesis ; Thyroid follicular cells
Internet Access
Description Access URL
http://nepis.epa.gov/Exe/ZyPDF.cgi?Dockey=300047EZ.PDF
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB88-230750 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 12/29/1988
Collation 169p
Abstract
EPA's Guidelines for Carcinogen Risk Assessment call for use of mechanistic and other relevant information in making choices about the models to be used in extrapolating hazard estimates from high to low exposures. The Forum report on thyroid neoplasia proposes that, under clearly specified conditions, chemical carcinogenesis in thyroid follicular cells can be analyzed as a threshold phenomenon, rather than assuming low-dose linearity as EPA customarily does for carcinogenic compounds. Specifically, for chemicals that induce tumors only in the thyroid gland and alter pituitary-thyroid status, EPA scientists would use metabolic, toxicological, and ancillary data on preneoplastic end points to identify a NOAEL or LOAEL as the basis for a cancer potency estimate. The Forum report reviews the physiology and biochemistry of normal thyroid-pituitary function, discusses factors influencing thyroid carcinogenesis, and analyzes human data on thyroid hyperplasia and neoplasia.