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RECORD NUMBER: 4 OF 8

OLS Field Name OLS Field Data
Main Title Health assessment document for beryllium.
Author Bayliss, D. L. ; Chen, C. W. ; Cogliano, V. J. ; Elias, R.
CORP Author Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office,
Year Published 1987
Report Number EPA/600/8-84/026F
Stock Number PB88-179205
Subjects Toxins. ; Beryllium--Toxicology.
Additional Subjects Beryllium ; Environmental surveys ; Industrial hygiene ; Epidemiology ; Air pollution ; Toxic substances ; Occupational safety and health ; Cancer
Internet Access
Description Access URL
http://nepis.epa.gov/Exe/ZyPDF.cgi?Dockey=30001EIZ.PDF
Holdings
Library Call Number Additional Info Location Last
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Status
NTIS  PB88-179205 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 01/01/1988
Collation 206 pages : illustrations ; 28 cm
Abstract
The chemical and geochemical properties of beryllium resemble those of aluminum, zinc, and magnesium. The resemblance is primarily due to similar ionic potentials which facilitate covalent bonding. The three most common forms of beryllium in industrial emissions are the metal, the oxide, and the hydroxide. The main routes of beryllium intake for man and animals are inhalation and ingestion. While the absorption of ingested beryllium is probably quite small, the chemical properties of beryllium are such that inhaled beryllium has a long retention time in the lungs, and thus, a greater potential for absorption. The tissue distribution of absorbed beryllium is characterized by depositions primarily in the skeleton where the biological half-time is fairly long. The lung is the critical organ of both acute and chronic non-carcinogenic effects. However, unlike most other metals, the lung effects caused by chronic exposure to beryllium may be combined with systemic effects, of which one common factor may be hypersensitization. Certain beryllium compounds have shown carcinogenic activity in various experimental animals by various routes of exposure, but not by ingestion per se. Epidemiologic studies are inadequate to demonstrate or refute a human carcinogenic potential. In terms of the weight-of-evidence for carcinogenicity, beryllium is judged to be in Group B2 signifying that the animal evidence for carcinogenicity is sufficient and that beryllium and its compounds are regarded as probably carcinogenic for humans.
Notes
"November 1987." Includes bibliographical references (pages 8-1-8-20). "EPA/600/8-84/026F." Microfiche.