||Effect of exposure to PAN and ozone on susceptibility to chronic bacterial infection /
Thomas, Gail Bottomley.
||IIT Research Inst., Chicago, IL. Life Sciences Research Div.;Health Effects Research Lab., Research Triangle Park, NC.
|| U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory,
||EPA 600/1-79/001; EPA-68-02-1273
Peroxyacetyl nitrate--Physiological effect. ;
Ozone--Physiological effect. ;
Respiratory infections ;
Experimental data ;
Guinea pigs ;
Laboratory animals ;
Infectious diseases ;
In vivo analysis ;
Mycobacterium tuberculosis ;
Respiratory system ;
Peroxyacetyl nitrate ;
Toxic substances ;
Streptococcus pyogenes ;
Immune responses ;
||Region 3 Library/Philadelphia, PA
||Region 4 Library/Atlanta,GA
||Research Triangle Park Library/RTP, NC
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||viii, 33 pages : illustrations ; 28 cm.
The effects of peroxyacetyl nitrate (PAN) and ozone (O3) on susceptibility of mice and guinea pigs to chronic and acute respiratory infections were studied. The agent used for the acute infectious disease was Streptococcus sp. whereas Mycobacterium tuberculosis served as the agent for chronic respiratory infection. A significant increase in mortality due to streptococcal pneumonia was seen upon a single 3-hr exposure to PAN in concentrations ranging from 14.8 to 28.4 mg/cu m 3. Multiple daily exposures to 4.9 or 7.4 mg/cu m 3 PAN 3 hr/day, 5 days/week for up to 3 weeks had no effect on mortality, survival rates, or ability to clear inhaled Streptococcus sp. from the lungs. Daily 3-hr exposures to 25.0 mg/cu m 3 PAN did not produce any marked changes in the chronic infection as measured by M. tuberculosis titers in the lungs. The diameter of erythemas, expressing the cutaneous delayed hypersensitivity reaction were persistently smaller in guinea pigs exposed to PAN than those exposed to air. Multiple exposures to 19.8 mg/cu m 3 PAN resulted in initial elevation of antibody titers, but depression of titers during the later (12 to 15 week) observation period. A single exposure to the same concentration of PAN resulted in a significant increase in total number of cells lavaged from their lungs but somewhat decreased levels of adenosine triphosphate (ATP). Exposure to 7.4 mg/cu m 3 PAN 3 hr/day, 5 days/week for 2 weeks resulted in reduced total cell counts and a significant reduction of ATP levels in alveolar macrophages.
"EPA-600/1-79-001." EPA contract no. 68-02-1273; EPA project officer: Donald E. Gardner. Includes bibliographical references (pages 31-32).