Record Display for the EPA National Library Catalog

RECORD NUMBER: 3 OF 3

OLS Field Name OLS Field Data
Main Title Influenza Virus-Specific Cytotoxic T-Lymphocyte Activity in Fischer 344 Rat Lungs as a Method to Assess Pulmonary Immunocompetence: Effect of Phosgene Inhalation.
Author Ehrlich, J. P. ; Gunnison, A. F. ; Burleson., G. R. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC. ;New York Univ. Medical Center, NY. Inst. of Environmental Medicine.
Publisher c1989
Year Published 1989
Report Number EPA/600/J-89/226;
Stock Number PB90-146044
Additional Subjects Lungs ; Respiration ; Toxicity ; Phosgene ; Body weight ; Rats ; Exposure ; Models ; Infectious diseases ; Reprints ; T lymphocytes ; Immunologic cytotoxicity ; Orthomyxoviruses ; Dose-response relationships
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB90-146044 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/15/1990
Collation 12p
Abstract
The study utilized a rat influenza virus-infectivity model to determine alterations in an important host antiviral immunological response following an acute 4.0 hr exposure to 1.0 ppm phosgene. The effect on the specific antiviral immune response of the pulmonary cytotoxic T lymphocyte (CTL) was determined as the measure of toxicity. A significant suppression in the CTL response was detected 10 days post infection, a time during which peak activity is normally detected in control rats. No alterations were detected in pulmonary cell populations at this time, indicating that phosgene exposure alters the functional CTL activity. The CTL activity is believed to be an important antiviral immunological defense mechanism. CTL activity is the first specific immunological defense mechanism; inadequate CTL activity resulting from toxicant exposure could result in an enhanced and significantly prolonged pulmonary virus infection. (Copyright (c) 1989 Hemisphere Publishing Corporation.)