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RECORD NUMBER: 2 OF 5

OLS Field Name OLS Field Data
Main Title Discriminative Stimulus Properties of Triadimefon: Comparison with Methylphenidate.
Author Perkins, A. N. ; Eckerman, D. A. ; MacPhail., R. C. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. ;North Carolina Univ. at Chapel Hill.
Publisher c1991
Year Published 1991
Report Number EPA/600/J-92/016;
Stock Number PB92-143882
Additional Subjects Fungicides ; Methylphenidate ; Discrimination learning ; Comparison ; Rats ; Dose-response relationships ; Sodium chloride ; Reprints ; Triadimefon
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB92-143882 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 08/28/1992
Collation 7p
Abstract
Two groups of rats (N=4 each) were trained to discriminate either triadimefon (40 mg/kg) or methylphenidate (4 mg/kg) from saline in a two-lever, milk-reinforced drug discrimination paradigm. Dose response functions were determined during 5-min extinction sessions. Both agents produced a dose-related increase in the percentage of responses that occurred on the drug lever. In the substitution phase of the study, rats trained to discriminate triadimefon were tested with methylphenidate and rats trained to discriminate methylphenidate were tested with triadimefon. Triadimefon substituted completely for methylphenidate and methylphenidate substituted completely for triadimefon. The results indicate that triadimefon can function as a discriminative stimulus and that it shares discriminative stimulus properties with methylphenidate.