Record Display for the EPA National Library Catalog

RECORD NUMBER: 1 OF 5

OLS Field Name OLS Field Data
Main Title Chronic Neonatal Organotin Exposure Alters Radial-Arm Maze Performance in Adult Rats.
Author Miller, Diane B. ; Eckerman, David A. ; Krigman, Martin R. ; Grant, Lester D. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1982
Report Number EPA-600/J-82-138;
Stock Number PB83-191536
Additional Subjects Toxicology ; Rats ; Laboratory animals ; Learning ; Memory ; Reprints ; Tin/sulfate-triethyl ; Hyperactivity
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB83-191536 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 9p
Abstract
Long-Evans rats were intubated with 0.3 or 1.0 mg/kg of triethyltin sulfate (TET) or 0.3 mg/kg of trimethyltin hydroxide (TMT) from postnatal day 3-29, 1.0 mg/kg of TMT was given on alternate days beginning on postnatal day 3. Learning and memory were assessed in an automated radial-arm maze when the rats were 180-200 days old. With this maze accuracy and activity data can be collected simultaneously. TET or TMT treatment resulted in an increase in the number of days required to adequately perform the radial-arm maze task, and a transient deficit in accuracy. However, the most pronounced effect in both TET and TMT treated animals was hyperactivity which became manifest on the second day of testing and persisted throughout the remainder of testing.