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OLS Field Name OLS Field Data
Main Title Evaluating the human health effects of hazardous wastes : reproduction and development, neurotoxicity, genetic toxicity and cancer /
Author Dyer, Robert S. ; Houk, V. S. ; Reiter, L. W.
Other Authors
Author Title of a Work
Dyer, Robert S.
Houk, V. S.
Reiter, L. W.
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher U.S. Environmental Protection Agency, Health Effects Research Laboratory,
Year Published 1991
Report Number EPA/600/D-91/236
Stock Number PB92-110352
Subjects Hazardous wastes.
Additional Subjects Health hazards ; Reproduction(Biology) ; Carcinogens ; Mutagens ; Nervous system ; Toxicity ; Test methods ; Salmonella typhimurium ; DNA damage ; Motor activity ; Mutagenicity tests ; Bioassay ; Dose-response relationships ; Humans ; Teratogens ; Hazardous wastes
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB92-110352 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 01/01/1988
Collation 20 pages ; 28 cm
Abstract
Several approaches are available for characterizing potential toxicity of wastes. The paper describes biological tests which are appropriate for identifying waste as neurotoxic, genotoxic, or likely to produce developmental or reproductive effects. The tests recommended are, for neurotoxicity a functional observational battery, coupled with a measure of motor (bodily movement) activity; for genetic toxicity, the 'Ames' test of mutagenicity in Salmonella and a test of clastogenicity (DNA damage); and for developmental and reproductive toxicity, the Chernoff-Kavlock assay and a multigenerational reproductive assay. In addition, the paper identifies several generic factors which must be considered in performing any evaluations of hazardous wastes.
Notes
Cover title. "EPA 600/D-91/236." Includes bibliographical references. Microfiche.
Contents Notes
EPA/600/D-91/236.