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OLS Field Name OLS Field Data
Main Title Species and Strain Comparison of Acute Neurotoxic Effects of Trimethyltin in Mice and Rats.
Author Chang, L. W. ; Wenger, G. R. ; McMillan, D. E. ; Dyer, R. S. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1983
Report Number EPA/600/J-83-049;
Stock Number PB84-101260
Additional Subjects Toxicology ; Central nervous system ; Pathology ; Comparison ; Mice ; Rats ; Laboratory animals ; Dosage ; Reprints ; Tin/trimethyl ; Neurotoxicity
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB84-101260 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 17p
Abstract
Pathological changes in the central nervous system in two strains of mice (BALB/c and C57BL/6) and two strains of rats as a result of trimethyltin (TMT) intoxication were compared. Both strains of mice were administered with trimethyltin chloride at a dosage of 3.0 mg TMT-C1/kg b.w. while both strains of rats were exposed to 7.5mg TMT-C1/kg b.w. Animals were sacrified at the time of development of observable neurological signs (tremor, aggression): 2 days for both strains of mice, 3 days for Long Evans (LE) rats, and 5 days for Sprague Dawley (SD) rats. It was found that there were both species and strain differences in TMT toxicity.