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RECORD NUMBER: 37 OF 60

OLS Field Name OLS Field Data
Main Title Monoamine Oxidase Inhibition Cannot Account for Changes in Visual Evoked Potentials Produced by Chlordimeform.
Author Boyes, W. K. ; Moser, V. C. ; MacPhail, R. C. ; Dyer, R. S. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1985
Report Number EPA/600/J-85/240;
Stock Number PB86-137049
Additional Subjects Toxicology ; Insecticides ; Inhibitors ; Insecticides ; Chlorine organic compounds ; Rats ; Laboratory animals ; Reprints ; Chlordimeform ; Evoked responses ; Formamidine/N-(chloro-tolyl)-n-n-dimethyl
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB86-137049 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 10p
Abstract
Chlordimeform (CDM), a formamidine insecticide and monoamine oxidase (MAO) inhibitor, has recently been shown to produce profound changes in visual evoked potentials of hooded rats (Dyer and Boyes, The Toxicologist, 3: 13, 1983). Two experiments were performed to determine if the evoked potential changes were a result of MAO inhibition. In the first, the degree of MAO inhibition in the brains of rats treated with CDM (1.0 to 100 mg/kg i.p.) was compared with that produced by MAO inhibitor pargyline (0.3 to 30 mg/kg i.p.). Both compounds preferentially inhibited MAO-B, although MAO-A was substantially inhibited at higher dosages. Pargyline was a relatively more potent MAO inhibitor than CDM, but not more efficacious. In the second study, pattern reversal evoked potentials (PREPs) and flash evoked potentials (FEPs) were recorded from groups of rats after treatment with either saline, 0.4 mg/kg pargyline, 20 mg/kg pargyline, or 40 mg/kg CDM.