||Hormonal Influences on DDT Metabolism in the White Rat.
Durham, William F. ;
Cueto, Jr., Cipriano ;
Hayes, Jr., Wayland J. ;
||Communicable Disease Center, Savannah, Ga.
Oxygen organic compounds ;
Laboratory animals ;
Experimental data ;
Body weight ;
DDE insecticide ;
Pesticide residues ;
Toxic substances ;
Propionic acid/(testosterone-ester) ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
The influence of diethylstilbestrol (DES) and testerone propionate (TP) on the storage of DDT and its metabolite, DDE, was studied in normal and in gonadectomized rats. As expected, TP dosage increased the growth of female rats while DES administration inhibited the growth of males. Both hormones inhibited gonadal growth. Rats that received either DDT or hormone showed an increased liver weight/body weight ratio as compared to control animals. This effect was more marked in males than in females. DES increased DDT and DDE storage in fat in the male while TP decreased these values in the female. Similar effects of hormone dosage were noted on the ratio of DDE to total DDT-derived material stored in fat.