||Subchronic Toxicity of Para-Cresol in Sprague Dawley Rats: MBA Chemical No. 25.
Dietz, D. ;
Mulligan, L. T. ;
||Research Triangle Inst., Research Triangle Park, NC. ;Microbiological Associates, Bethesda, MD.;Environmental Protection Agency, Washington, DC. Office of Solid Waste.
Laboratory animals ;
Para cresol ;
CAS 106-44-5 ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
The study examined the oral toxicity of para-cresol (p-cresol) in Sprague Dawley rats during 13 weeks of oral gavage administration. Dose levels studied were 0, 50, 175 and 600 mg/kg/day. Three females treated with the high dose of p-Cresol died during the first three days of the study. Signs of central nervous system (CNS) depression were apparent in high-dose males and females. Reductions in body weight gain were seen for males and females treated at the high dose level and to a lesser extent in the mid dose males. Para-cresol was hepatotoxic, nephrotoxic, and induced a mild anemic state. Based on the results of the present investigation, 50 mg/kg/day appears to be the level at which no toxic effects were observed under the conditions of the present study.