Record Display for the EPA National Library Catalog

RECORD NUMBER: 14 OF 19

OLS Field Name OLS Field Data
Main Title Subchronic Toxicity of Meta-Cresol in Sprague Dawley Rats: MBA Chemical No. 24 (Revised).
Author Dietz, D. ; Mulligan, L. T. ;
CORP Author Research Triangle Inst., Research Triangle Park, NC. ;Microbiological Associates, Bethesda, MD.;Environmental Protection Agency, Washington, DC. Office of Solid Waste.
Year Published 1988
Report Number EPA-68-01-7075; EPA/530/SW-88/026;
Stock Number PB88-195284
Additional Subjects Toxicology ; Dosage ; Ingestion(Biology) ; Bioassay ; Laboratory animals ; Pathology ; Mortality ; Meta cresol ; CAS 108-39-4 ; 3-cresol
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB88-195284 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 09/04/1988
Collation 337p
Abstract
The study examined the toxic effects of meta-cresol in Sprague Dawley rats following 13 weeks of oral gavage administration. Dose levels studied were 0, 50, 150 and 450 mg/kg/day. The biological effects of m-cresol, central nervous system depression and reductions in body weight gain, were generally restricted to the high dose level under the conditions of the present study. Although a slight reduction in weight gain also occurred for mid-dose males but not females, no other manifestations of m-cresol toxicity were seen for these animals or for those at the low dose level. Thus, 50 mg/kg/day for meta-cresol administered to male and female Sprague Dawley rats for 13 weeks appears to represent the maximum dose tested in the study that produced no evident adverse effects.