||Subchronic Toxicity of Meta-Cresol in Sprague Dawley Rats: MBA Chemical No. 24 (Revised).
Dietz, D. ;
Mulligan, L. T. ;
||Research Triangle Inst., Research Triangle Park, NC. ;Microbiological Associates, Bethesda, MD.;Environmental Protection Agency, Washington, DC. Office of Solid Waste.
Laboratory animals ;
Meta cresol ;
CAS 108-39-4 ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
The study examined the toxic effects of meta-cresol in Sprague Dawley rats following 13 weeks of oral gavage administration. Dose levels studied were 0, 50, 150 and 450 mg/kg/day. The biological effects of m-cresol, central nervous system depression and reductions in body weight gain, were generally restricted to the high dose level under the conditions of the present study. Although a slight reduction in weight gain also occurred for mid-dose males but not females, no other manifestations of m-cresol toxicity were seen for these animals or for those at the low dose level. Thus, 50 mg/kg/day for meta-cresol administered to male and female Sprague Dawley rats for 13 weeks appears to represent the maximum dose tested in the study that produced no evident adverse effects.