||Characteristics of the U.S. EPA's Office of Pesticide Programs' Toxicity Information Databases.
Dearfield, K. L. ;
Quest, J. A. ;
Whiting, R. J. ;
Stack, H. F. ;
Waters, M. D. ;
||Environmental Health Research and Testing, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Data bases ;
Health hazards ;
Peer review ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
The United States Environmental Protection Agency's (USEPA's) Office of Pesticide Programs (OPP) requires that data from toxicity testing be submitted to the OPP to support the registration of pesticide chemicals. Once these data are submitted, they are entered into various toxicity data bases. The studies themselves are cataloged in an archival data base to allow retrieval of the study for review. Reviews of toxicity studies are then placed into a separate data base which can be retrieved to support a regulatory position. Toxicity information for health effects other than cancer and gene mutations from chronic exposure is reviewed through a reference dose (RfD) approach and these decisions and supporting data are entered into an RfD data base. Carcinogenicity data are reviewed by a Peer Review Process and these decisions will be entered into a newly developed data base to show the regulatory decision with supporting data. The mutagenicity data are reviewed and acceptable data are entered into the Genetic Activity Profile system to catalog and display the submitted information. These data bases contain the information used for hazard evaluations as part of the OPP review of pesticide chemicals.