Record Display for the EPA National Library Catalog

RECORD NUMBER: 7 OF 8

OLS Field Name OLS Field Data
Main Title Pulmonary and Systemic Health Effects of Acute and Subchronic Exposure to Smoke Obscurant SGF-2.
Author Grose, E. C. ; Selgrade, M. J. K. ; Dean, K. ; Hatch, G. E. ; Jaskot, R. J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC.
Year Published 1985
Report Number EPA/600/D-85/201;
Stock Number PB86-102928
Additional Subjects Toxicology ; Smoke ; Rats ; Exposure ; Laboratory animals ; Dosage ; Respiratory system ; Fog oil ; SGF-2
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB86-102928 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 21p
Abstract
Sixty-day old, male rats were exposed to air, 0.5 or 1.5 ml/1 fog-oil for 3.5 hr/d, 4 days/wk for either 4 or 13 wk. Following the acute (4 wk) exposure to 1.5 mg/1, a multifocal pneumonitis was observed. Lung lavage fluid had an elevated number of polymorphonuclear leukocytes, alveolar macrophages, total cells and an increase in lavage fluid protein. Lung wet and dry weights were increased. A lesser increase in the number of alveolar macrophages and lung weights was observed after exposure to 0.5 mg/1. Pulmonary function tests revealed an increase in end expiratory volume (EEV) in animals exposed to 1.5 mg/1. A decrease in zoxazolamine-induced paralysis time was observed following both 0.5 and 1.5 mg/1, however, no effect on pentobarbital-induced sleep time was observed. The subchronic (13 wk) exposures resulted in decreased body weight and increased lung dry weights at both 0.5 and 1.5 mg/1, an increase in lavage fluid protein and EEV following exposure to the 1.5 mg/1 concentration. Zoxazolamine paralysis time, which was decreased after both concentrations, correlated with an increase in aryl hydroxylhydrolase (AHH) activity in the liver. In conclusion, it appears that inhalation of smoke SGF-2 causes minimal pulmonary and systemic effects.