||Effects of Diphenylhydatoin and Chloroquine on Monkey Liver Microsomal Mixed-Function Oxidases.
Davis, J. E. ;
Cramer, M. F. ;
Peoples., A. J. ;
||Health Effects Research Lab., Research Triangle Park, N.C. Population Studies Div. ;National Center for Toxicology Research, Jefferson, Ark. ;Miami Univ., Fla. School of Medicine.
Laboratory animals ;
In vitro analysis ;
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Sixteen adult male squirrel monkeys (Saimiri sciureus) were randomly divided into three treatment groups and one control group. Each treatment group received 10 mg/kg oral doses of diphenylhydantoin and/or chloroquine. Following sacrifice, in vitro assays for activity of liver microsomal mixed-function oxidases were run. The assays confirmed diphenylhydantoin as a potent inducer of mixed-function oxidases. Chloroquine administration had little affect on the enzymes assayed and did not inhibit the diphenylhydantoin induction. (Copyright (c) 1977 by Hemisphere Publishing Corporation.)