Record Display for the EPA National Library Catalog
RECORD NUMBER: 27 OF 47Main Title | Metabolism and DNA Adduct Formation of 2-Acetylaminofluorene by Bladder Explants from Human, Dog, Monkey, Hamster and Rat. | |||||||||||
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Author | Schut, H. A. J. ; Daniel, F. B. ; Schenck, K. M. ; Loeb, T. R. ; Stoner, G. D. ; | |||||||||||
CORP Author | Medical Coll. of Ohio at Toledo.;Health Effects Research Lab., Research Triangle Park, NC. | |||||||||||
Year Published | 1984 | |||||||||||
Report Number | EPA/600/J-84/164; | |||||||||||
Stock Number | PB85-146801 | |||||||||||
Additional Subjects | Environmental surveys ; Biochemistry ; Malignant neoplasms ; Toxicology ; Metabolism ; Deoxyribonucleic acids ; Bladders ; Amines ; Laboratory animals ; Dogs ; Monkeys ; Rats ; Aromatic compounds ; Industrial hygiene ; Chemical bonds ; Reprints ; Cancer ; Occupational safety and health ; Fluorene/acetyl-amino | |||||||||||
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Collation | 8p | |||||||||||
Abstract | It is concluded that bladder explants of the human, dog, monkey, hamster, and rat metabolize AAF mainly to ring-hydroxylated products, but also form small amounts of the proximate carcinogenic metabolite N-hydroxy-AAF. Neither the overall binding of AAF to bladder DNA, nor the formation of specific AAF-DNA adducts is correlated with the relative susceptibilities of these five species to aromatic amine-induced urinary bladder carcinogenesis. |