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RECORD NUMBER: 55 OF 60

OLS Field Name OLS Field Data
Main Title Temperature-Dependent Changes in Visual Evoked Potentials of Rats (Journal Version).
Author Hetzler, B. E. ; Boyes, W. K. ; Creason, J. P. ; Dyer, R. S. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher 1988
Year Published 1988
Report Number EPA/600/J-88/150;
Stock Number PB89-119390
Additional Subjects Visual evoked potentials ; Body temperature ; Electrophysiology ; Hypothermia ; Laboratory animals ; Reprints ;
Holdings
Library Call Number Additional Info Location Last
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Status
NTIS  PB89-119390 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/14/1989
Collation 20p
Abstract
The effects of alterations in body temperature on flash and pattern reversal evoked potential (FEPs and PREPs) were examined in hooded rats whose thermoregulatory capacity was compromised with lesions of the preoptic/anterior hypothalamic area and/or cold restraint. Body temperature, measured with a rectal thermometer, was manipulated via exposure to different ambient temperatures. To describe the data, a model was used in which both linear and quadratic relationships could be estimated. PREP amplitudes were not significantly influenced by body temperature over the range of 27 - 42 C, although in one experiment FEP amplitudes did show a linear decline as temperatures fell below approximately 30 C. Both FEP and PREP latencies were strongly influenced by temperature, and became progressively longer as body temperature was lowered. The nonlinear component affecting latencies became more prominent as body temperature dropped lower and lower. These data demonstrate the temperature-dependence of FEP and PREP latencies independence of anesthetic or other drugs.