A number of tests and test batteries have been developed and implemented for detecting potential neurotoxicity in humans. In some cases test results may suggest specific dysfunction. While tests in laboratory animals are often used to project the potential for adverse health effects in humans, reverse extrapolation may also be desirable. When changes in physiological measures are indicated in humans, it may be important to pinpoint the nature of the effect and understand its underlying biology. A first step in this process can be taken using animal models with demonstrated homology to the human case. The paper will focus upon 3 physiological methods which have been used in the neurological clinic to evaluate sensory function in humans, and which have also been used in laboratory animals to evaluate toxicant-induced dysfunction.