||Early Effects of Trimethyltin on the Dentate Gyrus Basket Cells: A Morphological Study.
Chang, L. W. ;
Dyer, R. S. ;
||Arkansas Univ. for Medical Sciences, Little Rock.;Health Effects Research Lab., Research Triangle Park, NC.
Laboratory animals ;
Electron microscopy ;
Heavy metals ;
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Electrophysiological evidence for reduction of recurrent inhibition in the dentate gyrus in animals exposed to trimethyltin (TMT) suggested alterations in the inhibitory neurons (basket cells) by TMT. The present study was designed to investigate the morphology of basket cells after TMT exposure. Long Evans hooded rats were injected with TMT chloride in a dose of 6.0 mg/kg b.w. Tissue samples from the dentate gyri were examined by both light and electron microscopy at 24 and 72 hours after TMT exposure. Except for isolated basket cell damage at 72 hours, no remarkable pathological changes were observed with light microscopy. Consistent with previous data, electron microscopy revealed that the basket cells of the dentate gyrus are large neurons situated just below the granule cell layer with characteristic large, infolded nuclei and intranuclear filamentous rods. Increased cytoplasmic density and degenerative changes of the Golgi complex were evident in the basket cells as early as 24 hours after TMT exposure.