Record Display for the EPA National Library Catalog
RECORD NUMBER: 36 OF 49
|OLS Field Name||OLS Field Data|
|Main Title||Prenatal Effects of Dieldrin and Photodieldrin in Mice and Rats.|
|Author||Chernoff, Neil ; Kavlock, Robert J. ; Kathrein, John R. ; Dunn, John M. ; Haseman., Joseph K. ;|
|CORP Author||National Environmental Research Center, Research Triangle Park, N.C. Pesticides and Toxic Substances Effects Lab.|
|Report Number||found in PB-280 889|
|Stock Number||PB-280 892, found in PB-280 889|
|Additional Subjects||Dieldrin ; Toxicology ; Pesticides ; Insecticides ; Chlorine organic compounds ; Pregnancy ; Ingestion(Biology) ; Rats ; Mice ; Dosage ; Body weight ; Lethal dosage ; Mortality ; Photochemistry ; Laboratory animals ; Bioassay ; Toxicity ; Reprints ; Toxic substances ; Teratogenesis ; Fetuses|
Doses of 1.5, 3.0, and 6.0 mg/kg/day of dieldrin and 0.15, 0.30, and 0.60 mg/kg/day of photodieldrin were administered to pregnant CD-1 mice and CD rats by gastric intubation on days 7-16 of gestation. The highest dose of dieldrin induced significant increases in liver/body weight ratios and reduced weight gain in mice, and resulted in 41% mortality in rats. The highest dose of photodieldrin also induced significant increases in mouse liver/body weight ratios, and resulted in 15% mortality in rats. Teratogenic effects were not observed. The higher doses of dieldrin induced an increase in supernumerary ribs and a concomitant decrease in ossification centers in fetal mice indicating toxicity at these dose levels. Similar changes were not found in the rat. Photodieldrin induced no apparent fetal toxicity in either species.
contained in PB-280 889 titled Journal Articles on Toxicology. Group 14.