Record Display for the EPA National Library Catalog
RECORD NUMBER: 7 OF 36Main Title | Drug toxicokinetics | |||||||||||
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Publisher | M. Dekker, | |||||||||||
Year Published | 1993 | |||||||||||
OCLC Number | 27813419 | |||||||||||
ISBN | 0824790197 (alk. paper) | |||||||||||
Subjects | Drugs--Toxicology ; Pharmacokinetics ; Drugs--toxicity ; Pharmacokinetics | |||||||||||
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Collation | xviii, 408 p. : ill., charts ; 24 cm. | |||||||||||
Notes | Includes bibliographical references and index. |
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Contents Notes | Analytical method considerations for toxicokinetic studies / D. Scott Wright -- Pharmacokinetic principles: linear and nonlinear / Peter G. Welling -- Biotransformation of xenobiotics to chemically reactive metabolites / Neal Castagnoli, Jr. and Kay P. Castagnoli -- Role of toxicokinetics in dose selection for carcinogenicity studies / Mitchell N. Cayen and Hugh E. Black -- Toxicokinetic study design and integrated programs / Eva Halperin-Walega, Avraham Yacobi and Vijay K. Batra -- Role of toxicokinetics in toxicity testing / L.F. Chasseaud -- Relation between toxicity and kinetics and models of renal disease / Norberto Perico and Silvio Garattini -- Route of administration and toxicity / Lloyd A. Dethloff -- Genetic variations in humans and toxicokinetics / Bert N. La Du, Jr. -- Comparative histokinetic and xenodynamic considerations in toxicity / Michael J. Iatropoulos -- Toxicokinetics of anticancer compounds / Lloyd R. Whitfield and David G. Pegg -- Toxicokinetics of chemical carcinogens / Anthony J. Streeter. (cont.) Application of toxicokinetic principles in the development of antiatherosclerotic compounds / Robert L. Susick and Thomas Woolf -- Toxicokinetics of drugs acting on the central nervous system / D. Scott Wright, Steven E. Rose and John R. MacDonald -- Toxicokinetics of antibacterial agents: preclinical perspective / Robert D. Smyth and Robert J. Smyth -- Perspective and future directions of toxicokinetics in drug development / Felix A. de la Iglesia. |