Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Effects of Diphenylhydatoin and Chloroquine on Monkey Liver Microsomal Mixed-Function Oxidases.
Author Davis, J. E. ; Cramer, M. F. ; Peoples., A. J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, N.C. Population Studies Div. ;National Center for Toxicology Research, Jefferson, Ark. ;Miami Univ., Fla. School of Medicine.
Year Published 1977
Report Number EPA/600/J-77/093;
Stock Number PB-278 598
Additional Subjects Drugs ; Oxidoreductases ; Enzymes ; Hydantoins ; Monkeys ; Bioassay ; Laboratory animals ; Ribosomes ; Liver ; In vitro analysis ; Reprints ; Hydantoin/diphenyl ; Chloroquine
Library Call Number Additional Info Location Last
NTIS  PB-278 598 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 8p
Sixteen adult male squirrel monkeys (Saimiri sciureus) were randomly divided into three treatment groups and one control group. Each treatment group received 10 mg/kg oral doses of diphenylhydantoin and/or chloroquine. Following sacrifice, in vitro assays for activity of liver microsomal mixed-function oxidases were run. The assays confirmed diphenylhydantoin as a potent inducer of mixed-function oxidases. Chloroquine administration had little affect on the enzymes assayed and did not inhibit the diphenylhydantoin induction. (Copyright (c) 1977 by Hemisphere Publishing Corporation.)