Main Title |
Acute Methanol Toxicity in Minipigs |
Author |
Dorman, David C. ;
Dorman, D. C. ;
Dye, J. A. ;
Nassise, M. P. ;
Ekuta, J. ;
Bolon, B.
|
Other Authors |
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Chemical Industry Inst. of Toxicology, Research Triangle Park, NC. ;North Carolina State Univ. at Raleigh. Coll. of Veterinary Medicine. |
Publisher |
Environmental Protection Agency, |
Year Published |
1993 |
Report Number |
EPA/600/J-94/392; |
Stock Number |
PB95-126520 |
OCLC Number |
47171722 |
Subjects |
Methanol as fuel--toxicity
|
Additional Subjects |
Miniature swine ;
Methanol ;
Toxicity ;
Animal disease models ;
Eye(Anatomy) ;
Central nervous system ;
Dose-response relationships ;
Pharmacokinetics ;
Formic acid ;
Reprints ;
|
Internet Access |
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
ELCD |
EPA 600-J-94-392 |
|
NVFEL Library/Ann Arbor, MI |
09/09/2011 |
NTIS |
PB95-126520 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
341-347p. : 28 cm. |
Abstract |
The pig has been proposed as a potential animal model for methanol-induced neuro-ocular toxicosis in humans because of its low liver tetrahydrofolate levels and slower rate of formate metabolism compared to those of humans. To examine the validity of this animal model, 12 4-month-old female minipigs (minipig YU) were given a single oral dose of water or methanol at 1.0, 2.5, or 5.0 g/kg body wt by gavage (n = 3 pigs/dose). Dose-dependent signs of acute methanol intoxication, which included mild CNS depression, tremors, ataxia, and recumbency, developed within 0.5 to 2.0 hr, and resolved by 52 hr. Methanol- and formate-dosed pigs did not develop optic nerve lesions, toxicologically significant formate accumulation, or metabolic acidosis. Based on results following a single dose, female minipigs do not appear to be overtly sensitive to methanol and thus may not be a suitable animal model for acute methanol-induced neuroocular toxicosis. |
Notes |
"EPA/600/J-94/392" Includes bibliographical references. |