Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Comparison of In vivo and In vitro Methods for Assessing the Effects of Phenobarbital on the Hepatic Drug-Metabolizing Enzyme System.
Author Chadwick, R. W. ; Copeland, M. F. ; Carlson, G. P. ; Trela, B. A. ; Most, B. M. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Purdue Univ., Lafayette, IN. School of Pharmacy and Pharmacal Sciences. ;Northrop Services, Inc., Research Triangle Park, NC.
Year Published 1985
Report Number EPA/600/J-85/371;
Stock Number PB86-187366
Additional Subjects Phenobarbital ; Toxicology ; Enzymes ; Comparison ; Parenteral infusions ; In viva analysis ; In vitro analysis ; Metabolism ; Rats ; Dosage ; Laboratory animals ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB86-187366 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 14p
The effect of daily i.p. injections of 0, 1, 10 and 80 mg/kg phenobarbital for 1 week on the activity of the hepatic drug-metabolizing enzyme system was measured in the rat by a model substrate assay employing lindane and by a battery of in vitro enzyme assays. Comparison of the dose-response curves of the in vivo and in vitro assays indicated that urinary metabolities of indane provided a good index of phenobarbital-induced change in both phase I and phase II reactions.