Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Interaction between Gamma-Hexachlorocyclohexane and the Gastrointestinal Microflora and Their Effect on the Absorption, Biotransformation, and Excretion of Parathion by the Rat.
Author Chadwick, R. W. ; Copeland, M. F. ; Froehlich, R. ; Cooke, N. ; Whitehouse, D. A. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1984
Report Number EPA/600/J-84/102;
Stock Number PB84-246438
Additional Subjects Parathion ; Insecticides ; Chlorobenzenes ; Gastrointestinal system ; Toxicity ; Laboratory animals ; Absorption ; In vivo analysis ; Environmental surveys ; Biochemistry ; Rats ; Chlorine organic compounds ; Reprints ; Lindane ; Cyclohexane/hexachloro ; Biotransformation
Library Call Number Additional Info Location Last
NTIS  PB84-246438 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 8p
Pretreatment of rats with the organochlorine insecticide lindane reduced the estimated absorption rate of parathion from the gastrointestinal tract. Lindane pretreatment also significantly reduced the metabolism of parathion to p-nitrophenol in vivo. Lindane pretreatment altered the gastrointestinal (GI) microflora by increasing the ratio of anaerobes to aerobes. Consistent with this alteration was a significantly greater retention of unaltered parathion and the microbial metabolite aminoparathion in the GI tract of the lindane-pretreated rats 1 h after the administration of parathion. Enhanced conversion of parathion to aminoparathion together with a slower absorption rate may play a role in the antagonism parathion toxicity by lindane.