Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Enhanced Pesticide Metabolism, A Previously Unreported Effect of Dietary Fibre in Mammals.
Author Chadwick, R. W. ; Copeland, M. F. ; Chadwick, C. J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1977
Report Number EPA/600/J-78/082;
Stock Number PB-290 342
Additional Subjects Pesticides ; Fibers ; Insecticides ; Chlorine organic compounds ; Metabolism ; Rats ; Diets ; Laboratory animals ; Ingestion(Biology) ; Radioactivity ; Excretion ; Tissues(Biology) ; Labeled substances ; Experimental data ; Tables(Data) ; Reprints ; Lindane ; Cyclohexane/hexachloro ; Dietary fibers ; Metabolites ; Toxic substances
Library Call Number Additional Info Location Last
NTIS  PB-290 342 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 11p
The effects of various dietary fibers on the metabolism of the organochlorine insecticide, lindane, were compared. Groups of six weanling female Sprague-Dawley rats were fed either a synthetic low-residue diet (LRD), LRD + 10% pectin, LRD + 10% agar, LRD + 10% cellulose, or Purina Lab Chow for 28 days. The animals were then dosed orally with 2.87 mg lindane and were killed 24 hr later. A smaller proportion of administered radioactivity was recovered in the excreta and selected tissues from the rats fed the LRD diet than from other groups and the fate of the radioactivity not accounted for was investigated in a second experiment using rats fed either LRD unsupplemented, LRD + 10% pectin or the standard chow diet. Pectin and the dietary fiber contained in Purina Lab Chow caused significant alterations in the metabolism of lindane. A significant increase in the excretion of radiolabelled products, a higher level of conjugated chlorophenols and polar metabolites, a significant alteration in the proportions of the excreted chlorophenols and significant stimulation of the enzymes involved in lindane metabolism indicated that dietary fiber such as pectin or the plant fiber in Purina Lab Chow can significantly affect the metabolism of xenobiotics in mammals.