Record Display for the EPA National Library Catalog

RECORD NUMBER: 10 OF 26

OLS Field Name OLS Field Data
Main Title Concentration of O,P'-DDT in Rat Brain at Various Intervals after Dosing.
Author Dale, W. E. ; Copeland, M. F. ; Pearce, G. W. ; Miles., J. W. ;
CORP Author Communicable Disease Center, Atlanta, Ga.
Year Published 1965
Stock Number PB-279 749
Additional Subjects DDT ; Pesticides ; Toxicology ; Concentration(Composition) ; Rats ; Brain ; Laboratory animals ; Experimental data ; Dosage ; Lethal dosage ; Ingestion(Biology) ; Bioassay ; Toxicity ; Reprints ; Toxic substances
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB-279 749 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 4p
Abstract
At the same oral dosage of 150 mg/kg, p,p'-DDT produces severe illness in all rats and kills about half of them, but o,p'-DDT produced no illness. However, the concentration of o,p'-DDT in the brain at various intervals after dosing was about the same as that reported by Dale et al. for p,p'-DDT given at the same dosage. At a dosage of 3000 mg/kg, o,p'-DDT produces mild to moderate illness and the concentration in the brain was 5 to 9 times the concentration of p,p'-DDT required to produce similar symptoms. The ethylene derivative of o,p'-DDT (o,p'-DDE) was not detected in any of the brains. Thus, p,p'-DDT appears to be inherently more toxic than the o,p'-isomer.