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RECORD NUMBER: 16 OF 70

OLS Field Name OLS Field Data
Main Title Comparative Mutagenicity of Halogenated Pyridines in the 'Salmonella Typhimurium'/Mammalian Microsome Test.
Author Claxton, L. D. ; Dearfield, K. L. ; Spanggord, R. J. ; Riccio, E. S. ; Moetelmans, K. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;SRI International, Menlo Park, CA.
Year Published 1987
Report Number EPA/600/J-87/027;
Stock Number PB87-198479
Additional Subjects Mutagens ; Salmonella typhimurium ; Ribosomes ; Pyridines ; Hazardous materials ; Toxicity ; Chemical tests ; Halogens ; Tables(Data) ; Reprints ;
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB87-198479 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 17p
Abstract
The Salmonella/microsome assay with strains TA97, TA98, TA100, and TA102 was used to examine the potential mutagenicity and structure-activity of 16 mono- and dihalogenated pyridines. The chemical reactivity of the halopyridines suggests that nucleophilic displacement of halogens can occur with halogens at positions 2, 4, and 6 being displaced in addition-elimination reactions. 2-Chloropyridine gave a positive result with rat liver metabolic activation, and 2-fluoropyridine gave equivocal results under these conditions. Mutagenic responses were also obtained with 2-chloromethyl pyridine and 3-chloromethyl pyridine, both in the presence and absence of rat liver S-9. These results suggest the halogenated pyridines, especially with halogens at the 2-position, and singly on a methyl substituent, have mutagenic activity in the Salmonella assay.