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RECORD NUMBER: 1 OF 70

OLS Field Name OLS Field Data
Main Title Analysis by Chemical Class of Salmonella Mutagenicity Tests as Predictors of Animal Carcinogenicity (Journal Version).
Author Claxton, L. D. ; Stead, A. G. ; Walsh, D. ;
CORP Author Environmental Health Research and Testing, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1988
Year Published 1988
Report Number EPA-68-02-4456; EPA/600/J-88/101;
Stock Number PB89-109326
Additional Subjects Toxicology ; Salmonella ; Carcinogens ; Predictions ; Methodology ; Laboratory animals ; Bioassay ; Reprints ; Mutagenicity tests
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB89-109326 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/14/1989
Collation 31p
Abstract
For a number of years, investigators have recognized that humans potentially are exposed to large numbers of genotoxicants. Many efforts have attempted to validate various short-term bioassays for use as rapid, inexpensive screens for genotoxicants--especially carcinogens. Salmonella mutagenicity as an indicator of potential carcinogenicity is examined by comparing published (and when possible, evaluated) Salmonella results with the evaluated Gene-Tox animal carcinogen data base. The Salmonella bioassay does especially well in those cases where the level of evidence for carcinogenicity is the strongest. Analysis shows that except for special classes of compounds, the plate-incorporation protocol and the preincubation protocol are equally efficient at detecting mutagens. The paper also demonstrates how validation values (sensitivity, specificity, etc.) vary with chemical class. Overall, the analysis demonstrates that when used and interpreted in a meaningful chemical class context, the Salmonella bioassay remains extremely useful in identifying potential animal carcinogens. (Copyright (c) 1988 Elsevier Science Publishers B.V.)