Record Display for the EPA National Library Catalog

RECORD NUMBER: 43 OF 49

OLS Field Name OLS Field Data
Main Title Role of Pharmacokinetic Modeling in Risk Assessment: Perchloroethylene (PCE) as an Example.
Author Chen, C. W. ; Blancato, J. N. ;
CORP Author Environmental Protection Agency, Washington, DC. Carcinogen Assessment Group.
Publisher Dec 86
Year Published 1986
Report Number EPA/600/D-90/045;
Stock Number PB90-221995
Additional Subjects Perchloryl compounds ; Carcinogens ; Bioassay ; Humans ; Rats ; Mice ; Reprints ; Pharmacokinetics ; Risk assessment ; Dose-response relationships
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB90-221995 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 08/27/1990
Collation 36p
Abstract
Available metabolic and pharmacokinetic data on perchloroethylene (PCE) are used as a basis for discussion of the use of such data in quantitative risk assessment. The emphasis is on methodologies for improving risk assessment rather than on the risk assessment of PCE per se. The data available on PCE are sufficient to independently construct a physiologically-based pharmacokinetic (PB-PK) model for each of the three species: humans, rats, and mice. The model is used to convert bioassay-administered doses into metabolized doses for dose-response calculation, to evaluate the effect of various exposure patterns on metabolized dose, and to compare inhalation risk estimates calculated on the basis of inhalation and gavage bioassay data. The advantages and limitations of using PB-PK models in risk assessment are addressed.