Record Display for the EPA National Library Catalog

RECORD NUMBER: 26 OF 100

OLS Field Name OLS Field Data
Main Title Effect of Lindane on Intestinal Nitroreductase, Azoreductase, SS-Glucuronidase, Dechlorinase, and Dehydrochlorinase Activity.
Author Chadwick, R. W. ; Chang, J. ; Forehand, L. R. ; Long, J. E. ; Duffy, M. C. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina Univ. at Chapel Hill. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC.
Publisher c1990
Year Published 1990
Report Number EPA/600/J-90/346;
Stock Number PB91-163600
Additional Subjects Lindane ; Small intestine ; Enzymology ; Glucuronidase ; Rats ; Intestinal mucosa ; Gas chromatography ; Enterobacteriaceae ; Reprints ; Nitroreductase ; Azoreductase ; Dechlorinase ; Dehydrochlorinase
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB91-163600 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/13/1991
Collation 11p
Abstract
The effect of daily p.o. injections of 20 mg/kg lindane on nitroreductase, azoreductase, B-glucuronidase, dechlorinase and dehydrochlorinase enzyme activity in the rat intestinal tract was investigated after 2 weeks and 5 weeks of treatment. Antibiotics were administered to half of the treated rats after 4 weeks of treatment. Results of the study indicated that lindane significantly increased nitro reductase and azoreductase activity in the small intestine, that there were regional differences in the effect of lindane as well as differences dependent on the exposure duration. The results also suggest the presence of substantial levels of mucosal enzyme in the small intestine.