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RECORD NUMBER: 8 OF 38

OLS Field Name OLS Field Data
Main Title Comparative Gastrointestinal Enzyme Activity and Activation of the Promutagen 2,6-Dinitrotoluene in Male CD-1 Mice and Male Fischer 344 Rats.
Author Chadwick, R. W. ; George, S. E. ; Chang, J. ; Kohan, M. J. ; Dekker., J. P. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina Univ. at Chapel Hill. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC.
Publisher c1990
Year Published 1990
Report Number EPA/600/J-90/169;
Stock Number PB91-115816
Additional Subjects Enzymes ; Gastrointestinal system ; Mutagens ; Toxicology ; Mice ; Rats ; Male ; Hepatuma ; In vitro analysis ; In vivo analysis ; Metabolism ; Bioassay ; Reprints ; Ditoluenes ; Species specificity ; Biotransformation ; Mutagenicity tests ; Carcinogenicity tests
Holdings
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Status
NTIS  PB91-115816 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/04/1991
Collation 9p
Abstract
Comparative intestinal nitroreductase, azo reductase, beta-glucuronidase, dechlorinase, and dehydrochlorinase activities in young male Fischer 344 rats and young male CD-1 mice were measured in vitro while the comparative biotransformation of 2, 6-dinitrotoluene to mutagenic metabolites was determined in vivo. The mice, which exhibit a high spontaneous incidence of hepatomas, had markedly greater nitroreductase activity and metabolized significantly more 2, 6-dinitrotoluene to mutagenic metabolites than did Fischer 344 rats, which show a low incidence of liver tumors. Results of this study indicate that species differences in the incidence of hepatomas may be influenced by microbial flora and/or the biotransformation of xenobiotics in the G.I. tract. (Copyright (c) Elsevier Scientific Publishers Ireland, Ltd.)