||Comparability of In vitro and In vivo Methods for the Determination of Alterations in Drug Metabolism.
Carlson, G. P. ;
Chadwick, R. W. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;Purdue Univ., Lafayette, IN. School of Pharmacy and Pharmacal Sciences.
Laboratory animals ;
In vitro analysis ;
In vivo analysis ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
The article reviews the use of model substrates to assess the capacity of the liver to metabolize xenobiotics via the myriad of drug metabolizing pathways available to it. The applicability of model compounds to act as predictors of in vivo drug metabolism in man and animals was evaluated, and the advantages and limitations of these assays are indicated. (Copyright (c) 1987 Elsevier Science Publishers B.V. (Biomedical Division.)