Record Display for the EPA National Library Catalog

RECORD NUMBER: 5 OF 38

OLS Field Name OLS Field Data
Main Title Comparability of In vitro and In vivo Methods for the Determination of Alterations in Drug Metabolism.
Author Carlson, G. P. ; Chadwick, R. W. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Purdue Univ., Lafayette, IN. School of Pharmacy and Pharmacal Sciences.
Year Published 1987
Report Number EPA/600/J-87/316;
Stock Number PB88-196332
Additional Subjects Liver ; Metabolism ; Drugs ; Toxicity ; Laboratory animals ; Humans ; In vitro analysis ; In vivo analysis ; Comparison ; Substrates ; Antipyrine ; Models ; Evaluation ; Reprints ; Xenobiotics
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB88-196332 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 09/04/1988
Collation 16p
Abstract
The article reviews the use of model substrates to assess the capacity of the liver to metabolize xenobiotics via the myriad of drug metabolizing pathways available to it. The applicability of model compounds to act as predictors of in vivo drug metabolism in man and animals was evaluated, and the advantages and limitations of these assays are indicated. (Copyright (c) 1987 Elsevier Science Publishers B.V. (Biomedical Division.)