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RECORD NUMBER: 34 OF 38

OLS Field Name OLS Field Data
Main Title Potentiation of 2,6-Dinitrotoluene Genotoxicity in Fischer 344 Rats by Pretreatment with Pentachlorophenol.
Author Chadwick, R. W. ; George, S. E. ; Chang, J. ; Kohan, M. J. ; Dekker, J. P. ;
CORP Author Environmental Protection Agency, Research Triangle Park, NC.;Air Force Office of Scientific Research, Bolling AFB, DC.
Publisher 1991
Year Published 1991
Report Number AFOSR-ISSA-90-0029; 2312; A4; AFOSR-TR-91-0433 ;
Stock Number AD-A235 140/1
Additional Subjects Animals ; Chlorine ; Enteric bacteria ; Germicides ; Intestines ; Liver ; Metabolites ; Mutagens ; Organic compounds ; Peanut oil ; Pesticides ; Urine ; Vehicles ; Organochlorine insecticides ; Dinitrotoluenes ; Pentachlorophenol ; Carcinogens ; Mixed function oxidases ; Mutagens
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  AD-A235 140/1 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 09/04/1991
Collation 15p
Abstract
The organochlorine pesticide, pentachlorophenol, a potent sulfotransferase inhibitor, reportedly reduces the binding of 2,6-dinitrotoluene, an industrial hepatocarcinogen to hepatic DNA by 95% after a single i.p. injection. Activation of 2,6-dinitrotoluene to genotoxic metabolites involves enzymes in both the liver and the intestinal flora. Since pentachlorophenol also has bactericidal activity and induces hepatic mixed function oxidase activity after longer treatment, the effect of pentachlorophenol on intestinal enzyme activity and the biotransformation of 2,6-dinitrotoluene to genotoxic metabolites was studied after 1, 2, 4, and 5 weeks of treatment. Male Fischer 344 rats were dosed daily, by gavage, with either 20 mg/kg pentachlorophenol or the peanut oil vehicle. After 1, 2, 4, and 5 weeks, select control and treated animals were injected p.o. with 75 mg/kg 2,6-dinitrotoluene and transferred to metabolism cages, where urine was collected for 24 hr and tested for mutagenic activity by the Ames Salmonella typhimurium reversion assay.