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RECORD NUMBER: 30 OF 38

OLS Field Name OLS Field Data
Main Title Metabolic Alterations in the Squirrel Monkey Induced by DDT Administration and Ascorbic Acid Deficiency.
Author Chadwick, R. W. ; Cranmer, M. F. ; Peoples., A. J. ;
CORP Author Environmental Protection Agency, Perrine, Fla. Perrine Primate Lab.
Year Published 1971
Stock Number PB-278 098
Additional Subjects Toxicology ; Pesticides ; Insecticides ; DDT ; Ascorbic acid ; Enzymes ; Metabolism ; Biochemistry ; Nutrition ; Detoxification ; Toxic tolerances ; Nutritional deficiencies ; Monkeys ; Laboratory animals ; Bioassay ; Dosage ; Dose rate ; Reprints ; Glucuronic acid ; Glucaric acid ; Toxic substances
Holdings
Library Call Number Additional Info Location Last
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Status
NTIS  PB-278 098 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 11p
Abstract
A daily po injection of 5 mg of 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) given to squirrel monkeys for a 2-wk period produces significant increases in liver weight, microsomal protein, cytochrome P-450 and the in vitro activity of various drug metabolizing enzymes. The results indicate that ascorbic acid deficiency may significantly impair both the induction of O-demethylase and the stimulation of the glucuronic acid system by DDT. The D-glucuronic/D-glucaric acid excretion ratio is significantly depressed within 2 days in monkeys fed the ascorbic acid deficient diet. In addition to ascorbic acid deficiency an unknown nutritional factor from the administration of a second lot of the ascorbic acid deficient diet also appears to cause an inhibition of the D-glucuronic/D-glucaric acid excretion ratio. This study provides evidence that interactions between nutritional status and toxic stress may significantly affect some routes of detoxification in the squirrel monkey.