||Antagonism of Chlorobenzene-Induced Hepatotoxicity by Lindane.
Chadwick, R. W. ;
Scotti, T. M. ;
Copeland, M. F. ;
Mole, M. L. ;
Froehlich, R. ;
||Health Effects Research Lab., Research Triangle Park, NC.
Chlorine organic compounds ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
In a 2x2 factorial designed experiment involving chlorobenzene and gamma-hexachlorocyclohexane (lindane), the hepatotoxicity induced by a challenge dose of chlorobenzene was altered by the pretreatments due to selective changes in various metabolic pathways. These changes resulted in either (1) a marginally significant decrease in hepatotoxicity (chlorobenzene-pretreatment); (2) significant reduction in both the incidence and severity of the lesions (lindane-pretreatment); or (3) absence of centrilobular hepatocellular necrosis in all but 1 of 12 rats where a minimal degree of necrosis was present (chlorobenzene + lindane-pretreatment).